Mirna Therapeutics

Further Reading

Scientific Reports

• Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.
  Calin, G. A., C. Sevignani, C. D. Dumitru, T. Hyslop, E. Noch, S. Yendamuri, M. Shimizu, S. Rattan, F. Bullrich, M. Negrini, and C. M. Croce. 2004. Proc Natl Acad Sci U S A 101:2999-3004.
• MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
  Chan, J. A., A. M. Krichevsky, and K. S. Kosik. 2005. Cancer Res 65:6029-33.
• miR-15 and miR-16 induce apoptosis by targeting BCL2.
  Cimmino, A., G. A. Calin, M. Fabbri, M. V. Iorio, M. Ferracin, M. Shimizu, S. E. Wojcik, R. I. Aqeilan, S. Zupo, M. Dono, L. Rassenti, H. Alder, S. Volinia, C. G. Liu, T. J. Kipps, M. Negrini, and C. M. Croce. 2005. Proc Natl Acad Sci U S A 102:13944-9.
• Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice.
  Costinean, S., N. Zanesi, Y. Pekarsky, E. Tili, S. Volinia, N. Heerema, and C. M. Croce. 2006. Proc Natl Acad Sci U S A 103:7024-9.
• Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
  Dews, M., A. Homayouni, D. Yu, D. Murphy, C. Sevignani, E. Wentzel, E. E. Furth, W. M. Lee, G. H. Enders, J. T. Mendell, and A. Thomas-Tikhonenko. 2006. Nat Genet 38:1060-5.
• A microRNA polycistron as a potential human oncogene.
  He, L., J. M. Thomson, M. T. Hemann, E. Hernando-Monge, D. Mu, S. Goodson, S. Powers, C. Cordon-Cardo, S. W. Lowe, G. J. Hannon, and S. M. Hammond. 2005. Nature 435:828-33.
• A microRNA component of the p53 tumour suppressor network.
  He, L., X. He, L. P. Lim, E. de Stanchina, Z. Xuan, Y. Liang, W. Xue, L. Zender, J. Magnus, D. Ridzon, A. L. Jackson, P. S. Linsley, C. Chen, S. W. Lowe, M. A. Cleary, and G. J. Hannon. 2007. Nature 447:1130-4.
• MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells.
  Ji, Q., Hao, X., Zhang, M., Tang, W., Yang, M., Li, L., Xiang, D., Desano, J. T., Bommer, G. T., Fan, D., Fearon, E. R., Lawrence, T. S., and L. Xu. 2009. PLoS One 28:e6816.
• Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.
  Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H. W., Chang, T. C., Vivekanandan, P., Torbenson, M., Clark, K. R., Mendell, J. R., and J. T. Mendell. 2009. Cell 137: 1005-17.
• Suppression of non-small cell lung tumor development by the let-7 microRNA family.
  Kumar, M. S., S. J. Erkeland, R. E. Pester, C. Y. Chen, M. S. Ebert, P. A. Sharp, and T. Jacks. Proc Natl Acad Sci U S A 105:3903-8.
• Impaired microRNA processing enhances cellular transformation and tumorigenesis.
  Kumar M.S., J. Lu, K. L. Mercer, T. R. Golub, and T. Jacks. 2007. Nat Genet.39:673-7.
• MicroRNA expression profiles classify human cancers.
  Lu, J., G. Getz, E. A. Miska, E. Alvarez-Saavedra, J. Lamb, D. Peck, A. Sweet-Cordero, B. L. Ebert, R. H. Mak, A. A. Ferrando, J. R. Downing, T. Jacks, H. R. Horvitz, and T. R. Golub. 2005. Nature 435:834.
• A microRNA DNA methylation signature for human cancer metastasis.
  Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez-Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., Gallagher, W. M., Eccles, S. A., Croce C. M., and M. Esteller. 2008. Proc Natl Acad Sci U S A 105:13556-61.
• Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation.
  Mayr, C., M. T. Hemann, and D. P. Bartel. 2007. Science 315:1576-9.
• The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
  Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., and G. Ruvkun. 2000. Nature 403: 901-6.
• miR-21-mediated tumor growth.
  Si, M. L., S. Zhu, H. Wu, Z. Lu, F. Wu, and Y. Y. Mo. 2007. Oncogene 26:2799-803.
• Endogenous human microRNAs that suppress breast cancer metastasis.
  Tavazoie S.F., C. Alarcón, T. Oskarsson, D. Padua, Q. Wang, P. D. Bos, W. L. Gerald, and J. Massagué J. 2008. Nature 451:147-52.
• A microRNA expression signature of human solid tumors defines cancer gene targets.
  Volinia, S., G. A. Calin, C. G. Liu, S. Ambs, A. Cimmino, F. Petrocca, R. Visone, M. Iorio, C. Roldo, M. Ferracin, R. L. Prueitt, N. Yanaihara, G. Lanza, A. Scarpa, A. Vecchione, M. Negrini, C. C. Harris, and C. M. Croce. 2006. Proc Natl Acad Sci U S A 103:2257-61.
• A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.
  Voorhoeve, P. M., C. le Sage, M. Schrier, A. J. Gillis, H. Stoop, R. Nagel, Y. P. Liu, J. van Duijse, J. Drost, A. Griekspoor, E. Zlotorynski, N. Yabuta, G. De Vita, H. Nojima, L. H. Looijenga, and R. Agami. 2006. Cell 124:1169-81
• MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy.
  Weidhaas, J. B., I. Babar, S. M. Nallur, P. Trang, S. Roush, M. Boehm, E. Gillespie, and F. J. Slack. 2007. Cancer Res.67:11111-6.
• Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.
  Yanaihara, N., N. Caplen, E. Bowman, M. Seike, K. Kumamoto, M. Yi, R. M. Stephens, A. Okamoto, J. Yokota, T. Tanaka, G. A. Calin, C. G. Liu, C. M. Croce, and C. C. Harris. 2006. Cancer Cell 9:189-98.
• let-7 regulates self renewal and tumorigenicity of breast cancer cells.
  Yu, F., H. Yao, P. Zhu, X. Zhang, W. Pan, C. Gong, Y. Huang, S. Hu, F. Su, J. Lieberman, and E. Song. Cell 131:1109-23.

Review articles

• MicroRNA signatures in human cancers.
  Calin, G. A., and C. M. Croce. 2006. Nat Rev Cancer 6:857-66.
• Oncomirs - microRNAs with a role in cancer.
  Esquela-Kerscher, A., and F. J. Slack. 2006. Nat Rev Cancer 6:259-69.
• 
  MicroRNAs: genomics, biogenesis, mechanism, and function D. P. Bartel (2004). Cell 116(2): 281-97.
• Regulatory RNAs: future perspectives in diagnosis, prognosis, and individualized therapy.
  Perron, M. P., V. Boissonneault, L. A. Gobeil, D. L. Ouellet, and P. Provost. 2007. Methods Mol Biol 361:311-26.
• Virus-encoded microRNAs: future therapeutic targets?
  Qi, P., J. X. Han, Y. Q. Lu, C. Wang, and F. F. Bu. 2006. Cell Mol Immunol 3:411-9
• MicroRNAs as a potential magic bullet in cancer.
  Slack, F. J., and J. B. Weidhaas. 2006. Future Oncol 2:73-82
• Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?
  Tong, A. W., and J. Nemunaitis. 2008. Cancer Gene Ther. 15:341-55.
• Molecular therapy in the microRNA era.
  Wurdinger, T., and F. F. Costa. 2006. Pharmacogenomics J 2007 Oct 7 (5):297-304.
• microRNAs as oncogenes and tumor suppressors.
  Zhang, B., X. Pan, G. P. Cobb, and T. A. Anderson. 2007. Dev Biol 302:1-12

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